Glycerylphosphorylcholine and choline glycerophosphate

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Glycerylphosphorylcholine and choline glycerophosphate.

In 1938-9 at the British Postgraduate Medical School, King & Aloisi isolated from dried pancreas a glycerophosphoric ester of choline which was found to be readily hydrolyzable. Evidence was also obtained for the existence of a dicholine ester. This work was published only in 1945 owing to war difficulties. In the same year Schmidt, Hershman & Thanmhauser (1945) reported the isolation of aglyce...

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Glycerophosphate/Acylglycerophosphate Acyltransferases

Acyl-CoA:glycerol-3-phosphate acyltransferase (GPAT) and acyl-CoA: 1-acyl-glycerol-3-phosphate acyltransferase (AGPAT) are involved in the de novo synthesis of triacylglycerol (TAG) and glycerophospholipids. Many enzymes belonging to the GPAT/AGPAT family have recently been identified and their physiological or pathophysiological roles have been proposed. The roles of GPAT/AGPAT in the synthesi...

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Targeting Mitochondrial Dysfunction with L-Alpha Glycerylphosphorylcholine

BACKGROUND We hypothesized that L-alpha-glycerylphosphorylcholine (GPC), a deacylatedphosphatidylcholine derivative, can influence the mitochondrial respiratory activity and in this way, may exert tissue protective effects. METHODS Rat liver mitochondria were examined with high-resolution respirometry to analyze the effects of GPC on the electron transport chain in normoxic and anoxic conditi...

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Glycerylphosphorylcholine diesterase activity of nervous tissue.

A study of the demyelinating diseases of man reveals at once the need for more knowledge of the enzymic processes that may be specifically concerned with the metabolism and maintenance ofthe myelin sheath of the nerve fibres. Experimental nerve degeneration and an accompanying break-up ofthe myelin sheath can beproduced in some species of animal, notably the hen, by the administration of certai...

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Lactic and Α-glycerophosphate Dehydrogenases in Insects

Different tissues, especially muscles, from insects belonging to various groups were extracted and studied for their lactic dehydrogenase (LDH) and alpha-glycerophosphate dehydrogenase (GDH I) activities from the comparative point of view. In all cases assays of flight muscle extracts showed extremely low values of LDH activity whereas the GDH activities were surprisingly high. The activities i...

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ژورنال

عنوان ژورنال: Biochemical Journal

سال: 1948

ISSN: 0306-3283

DOI: 10.1042/bj0430157